ßMETHOD FOR IDENTIFYING MODULATORS OF LRRTM1, LRRTM2 AND LRRTM4 USEFUL FOR TREATING ALZHEIMER'S DISEASE

摘要

Methods for identifying modulators of LRRTM1, LRRTM2 and LRRTM4 are described. The methods are particularly useful for identifying analytes that stimulate LRRTM1or LRRTM2 activity or inhibit LRRTM4 activity such that they antagonize processing of amyloid precursor protein (APP) to Aß peptide (Aß). Such methods can be used to identify analyties for treating Alzheimer disease.