摘要 |
<p>Disclosed herein are antigen-binding molecules, such as antibodies, that specifically recognize a portion of the EGFR C-terminal (intracellular) regulatory domain that interacts with one or more regulatory molecules (such as Suppressor of Cytokine Signaling ("SOCS") proteins). In certain normal or neoplastic cells and/or tissues, this region is inaccessible to the disclosed antigen-binding molecules. Thus, such antigen-binding molecules are useful at least to interrogate the regulated state of EGFR, predict the response of a cancer patient to EGFR inhibitor therapies, and/or predict the aggressiveness of neoplasms.</p> |
申请人 |
VENTANA MEDICAL SYSTEMS, INC.;POWELL, WILLIAM, C.;WILLOUGHBY KIVI, LINDA;ROCHE, PATRICK, C.;GOOCH, GARY;GAIRE, FABRIEN |
发明人 |
POWELL, WILLIAM, C.;WILLOUGHBY KIVI, LINDA;ROCHE, PATRICK, C.;GOOCH, GARY;GAIRE, FABRIEN |