AN AGENT FOR TREATMENT OF INFLAMMATION

摘要

The present disclosure relates to the use of an agent for treating an individual afflicted with an inflammatory condition or disease; the agent comprising one or more members of a group consisting of: (i) a polyoxyl hydrogenated castor oil; (ii) a reaction product of ethylene oxide with hydrogenated castor oil; (iii) one or more of a glycerol polyethylene glycol oxystearate and a fatty acid glycerol polyglycol ester, combined with one or more of a polyethylene glycol and glycerol ethoxylate; (iv) one or combination of plant-derived medium chain triglycerides. The agent may be used in conjugation with an anti-inflammatory drug, such as methotrexate, with an A3 adenosine receptor agonist and/or with folic acid. The inflammatory condition or disease is preferably an autoimmune disease. The present disclosure also concerns pharmaceutical compositions comprising the agent as well as methods for treatment of an inflammatory condition or disease. One agent in the context of the present disclosure may be Cremophor, e.g. Cremophor RH40, which may be used in combination with the anti-inflammatory agent, methotrexate (MTX).