PROCESS FOR THE EFFICIENT PREPARATION OF 3-HYDROXY PYRROLIDINE AND DERIVATIVES THEREOF

摘要

A production method of 3-hydroxypyrrolidine is provided to accomplish the simplification of reaction process and yield improvement by applying the reaction of each step to the next reaction without purifying process. The production method of 3-hydroxypyrrolidine comprise the steps of: (a) protecting -OH of 4-hollow-3-hydroxybutyric acid ester; (b) reducing the ester group of the compound obtained from the step (a) to prepare the corresponding alcohols; (c) reacting the alcohols obtained from the step (b) with sulfonylhalide to prepare the corresponding sulfonate; (d) reacting the sulfonate obtained from the step (c) with primary amine to prepare the hydroxy-protected pyrrolidine; and (e) deprotecting the compound obtained from the step (d) to prepare 3-hydroxy pyrrolidine.