The present invention provides a nucleic acid which comprises a non-specific promoter and at least one sequence that encodes a polypeptide that has at least one heterologous T cell epitope therein but does not have any regulatory T cell epitopes. The polypeptide may be one chain of a heterodimer, the heterologous T cell epitope causing disruption of the heterodimer chain such that it cannot bind with the other chain of the heterodimer. The nucleic acid can be used to raise a T cell response against the at least one heterologous T cell epitope.
申请公布号
WO2008116937(A3)
申请公布日期
2009.01.22
申请号
WO2008EP53761
申请日期
2008.03.28
申请人
SCANCELL LIMITED;DURRANT, LINDA GILLIAN;METHERINGHAM, RACHAEL LOUISE;PUDNEY, VICTORIA ANNE
发明人
DURRANT, LINDA GILLIAN;METHERINGHAM, RACHAEL LOUISE;PUDNEY, VICTORIA ANNE