PREPARATION OF N-ALKYLATED OPIATES BY REDUCTIVE AMINATION
摘要
<p>The present invention is directed to the reduction of an N-imine moiety or a hemiaminal moiety of a morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.</p>
申请公布号
WO2009012005(A1)
申请公布日期
2009.01.22
申请号
WO2008US67058
申请日期
2008.06.16
申请人
MALLINCKRODT INC.;GROTE, CHRISTOPHER, W.;ORR, BRIAN;JIANG, TAO;CANTRELL, GARY, L.
发明人
GROTE, CHRISTOPHER, W.;ORR, BRIAN;JIANG, TAO;CANTRELL, GARY, L.
