MONOCLONAL ANTIBODIES AGAINST DENGUE AND OTHER VIRUSES WITH DELETION IN FC REGION
摘要
The present invention relates to a variant of a parent polypeptide comprising an Fc region, which variant binds an Fc gamma receptor (Fc?R) with lower affinity than the parent polypeptide and comprises a deletion of at least one amino acid in about position 100 to about position 150 in the Fc region and related nucleic acids, vectors, host cells and methods of producing the variant and methods for preventing or treating a disorder in a mammal.
申请公布号
WO2009011941(A2)
申请公布日期
2009.01.22
申请号
WO2008US59313
申请日期
2008.04.03
申请人
THE GOVERNMENT OF U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMETNT OF HEALTH & HUMAN SERVICES;GONCALVEZ, ANA, P.;PURCELL, ROBERT, H.;LAI, CHING-JUH