摘要 |
The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt thereof (in which X 1 - X 5 , R 5 - R 8b , Z 1 - Z 2 and Ar 1 are defined herein), pharmaceutical compositions including those compounds and a process for making those compounds. The compounds of formula (I) are useful for treating pain, bladder overreactivity, urinary incontinence, inflammatory hyperalgesia by inhibiting the VR1 receptor in mammals.
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申请人 |
ABBOTT LABORATORIES |
发明人 |
GOMTSYAN, ARTHUR;BAYBURT, EROL, K.;LEE, CHIH-HUNG;KOENIG, JOHN, R.;SCHMIDT, ROBERT;LUKIN, KIRILL;CHAMBOURNIER, GILLES;HSU, MARGARET;LEANNA, ROBERT, M.;CINK, RUSSEL, D. |