发明名称 |
TRANSDERMALLY ABSORBABLE DONEPEZIL PREPARATION |
摘要 |
Disclosed is a donepezil-containing transdermally absorbable preparation which develops reduced adverse side effects and shows a satisfactory level of therapeutic effect. The preparation comprises an adhesive and a donepezil component (containing crystalline donepezil having type-B crystal polymorphism) and/or a salt thereof, wherein the donepezil component or the salt thereof is contained in an amount of 9 to 50% by mass relative to the total weight of the adhesive. The preparation (particularly, one having a non-aqueous adhesive layer) shows an excellent penetration of donepezil and/or a salt thereof into the skin, retains good stability of the active ingredient therein, and is remarkably reduced in local stimulation and adverse side effects. |
申请公布号 |
EP2016941(A1) |
申请公布日期 |
2009.01.21 |
申请号 |
EP20070742960 |
申请日期 |
2007.05.08 |
申请人 |
HISAMITSU PHARMACEUTICAL CO., INC. |
发明人 |
TERAHARA, TAKAAKI;MICHINAKA, YASUNARI;NAKANISHI, MASARU;HATTORI, WATARU;KURODA, TAKAO;AIDA, KAZUNOSUKE |
分类号 |
A61K31/445;A61K9/70;A61K47/32;A61P25/28;C07D211/32 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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