发明名称 |
METHOD FOR THE PRODUCTION OF ANTIBODIES IN IMMUNODEFICIENT ANIMAL INJECTED WITH HUMAN FETAL LIVER STEM CELLS |
摘要 |
<p>The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.</p> |
申请公布号 |
EP2016099(A1) |
申请公布日期 |
2009.01.21 |
申请号 |
EP20070725008 |
申请日期 |
2007.05.09 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
LIFKE, ALEXANDER;LIFKE, VALERIA;MUELLER-BECKMANN, BERND;SCHNITZER, TOBIAS |
分类号 |
C12N5/074;C12N5/0781 |
主分类号 |
C12N5/074 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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