SIVMAC239 IMMUNOGENIC PLASMIDS AND AIDS DNA VACCINE CONTAINING THE SAME

摘要

The immunogenic plasmid of SIVmac239(Simian Immunodeficiency Virus) is provided to minimize the immunity disturbance activity of the supplementary gene and optimize the codon to increase the expression efficiency of the inserted gene, thereby increasing the expression efficiency and immune efficacy of immunogen. The plasmid comprises the gene vif derived from SIVmac239, the signal sequence of secretory protein which is linked to the 3'-terminal of the gene vif, and the gene nef derived from SIVmac239 linked to the 5-terminal of the gene vif.