| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention concerns chemistry of adamantane derivatives, namely to a new method of obtaining of dialkylamides of 3-brome-1-adamantilalkancarbon acids of the general formula: ^ R1,R2=H:R3=N(C2H5)2 ^ R1, R2=CH3:R3=N(C2H5)2 ^ which can be of interest as semiproducts in synthesis of some biologically active substances possessing antiviral activity. Method lies in interaction of 1,3-dehydroadamantane with dialkylamides of alpha-bromalkancarbon acids from the row: diethylamide of alpha-bromacetic acid, piperidide of alpha-brompropionic acid, diethylamide of alpha-bromo-isobutyric acid at mole ratio of reagents peer accordingly 1:3-4, in the environment of the initial dialkylamides of alpha-bromalkancarbon acids, at temperature of 80-90°C within 4-6 hours. ^ EFFECT: obtaining of bonds of declared structural formula, excluding reception stage adamantilealkanecarbon acids. ^ 3 ex |
