DETERMINATION OF SLURRY CONCENTRATION

摘要

A method for determining the concentration of a chromatographic medium in a liquid slurry compiises the steps of providing a column (1) having a top end (3) and a bottom end (2) and adapted to retain a chromatographic medium therein, introducing a defined volume of the slurry (15) into the column (1), providing a liquid flow through the column (1) from the top end to the bottom end of the column to settle the chromatographic medium in the column, measuring the bed height of the consolidated chromatographic medium or a value related thereto, and determining from the measured bed height or value related thereto the concentration, or a value related to the concentration of the chromatographic medium in the slurry. A device for performing the method as well as the use of the method in packing of especially large scale columns are also disclosed.