PEPTIDE COMPOUNDS WITH TRANSIENT BIODEGRADABLE PEGYLATION

摘要

The present invention relates to peptides with biodegradable and transient pegylation and of the general formula (V); as well as a process for preparing such compounds, and intermediates for use in their preparation. Examples of such compounds include conjugates of GLP-1, exendin, growth hormone, and blood coagulation factor VIII, and the invention also relates to such peptides for use as a medicament, as well as corresponding pharmaceutical compositions. The compounds provide drugs with a protracted profile of action