SEIZURE FORECASTING, MICROSEIZURE PRECURSOR EVENTS, AND RELATED THERAPEUTIC METHODS AND DEVICES

摘要

A multiscale recording and stimulation system for identifying and responding to epileptiform activity. The system includes the use of microelectrode arrays (e.g., 10 - 100 micron electrodes with 100 - 500 micron spacing) to monitor iEEG activity of submillimeter regions or islands in the epileptogenic zone of brain tissue (e.g., independent microdomains in the range of 100-1000 micron diameter).