摘要 |
The present invention provides a method for treating tumors or tumor metastases in a patient, comprising administering to said patient simultaneously or sequentially a therapeutically effective amount of a combination of an anti-cancer agent or treatment that elevates pAkt levels in tumor cells and an mTOR inhibitor that binds to and directly inhibits both mTORC1 and mT0RC2 kinases. Examples of such anti-cancer agents or treatments incude doxorubicin, cisplatin, or ionizing radiation. The present invention also provides a pharmaceutical composition comprising an anti-cancer agent or treatment that elevates pAkt levels in tumor cells and an mTOR inhibitor that binds to and directly inhibits both mTORC1 and mT0RC2 kinases, in a pharmaceutically acceptable carrier. The present invention also provides a method for treating tumors or tumor metastases in a patient, comprising administering to said patient simultaneously or sequentially a therapeutically effective amount of a combination of the anti-cancer agent melphalan or 5-FU, and an mTOR inhibitor that binds to and directly inhibits both mTORC1 and mT0RC2 kinases. |
申请人 |
OSI PHARMACEUTICALS INC.;BARR, SHARON;BUCK, ELIZABETH;EYZAGUIRRE, ALEXANDRA;RUSSO, SUZANNE;BHAGWAT, SHRIPAD |
发明人 |
BARR, SHARON;BUCK, ELIZABETH;EYZAGUIRRE, ALEXANDRA;RUSSO, SUZANNE;BHAGWAT, SHRIPAD |