<p>The invention provides 17 AAG encapsulated in micelle particles. The micelles can be comprised of safe poly(ethylene glycol)-block-poly(lactic acid) (PEG-PLA). A significant advantage of PEG-PLA as a carrier is that it is less toxic than Cremophor® EL or DMSO. Additionally, PEG-PLA micelles are easier to handle than DMSO and they do not possess foul odors, which is a problem associated with 17-AAG formulations currently in clinical trials. The invention also provides methods of preparing active agents encapsulated micelles and therapeutic methods of using the micelles and their corresponding formulations, such as for the inhibition of Hsp 90, and/or for the treatment of cancer.</p>
申请公布号
WO2009009067(A2)
申请公布日期
2009.01.15
申请号
WO2008US08417
申请日期
2008.07.09
申请人
KWON,, GLEN, S.;FORREST, M., LAIRD;DAVIES, NEAL, M.
发明人
KWON,, GLEN, S.;FORREST, M., LAIRD;DAVIES, NEAL, M.