| 摘要 |
It is intended to provide a simple normal-pressure glaucoma model capable of spontaneously, month age-dependently and surely developing conditions similar to the symptom of normal-pressure glaucoma which occurs more frequently in elder patients and a method of evaluating a therapeutic effect on normal-pressure glaucoma whereby a drug useful in treating and diagnosing can be conveniently screened by using the above-described model. A normal-pressure glaucoma model comprising a nonhuman mammal, which is deficient in a transcriptional regulator NF-?Bp50 and thus spontaneously develops the normal-pressure glaucoma symptom month age-dependently, an organ or a tissue thereof or cells collected from any of the same. A method of evaluating a therapeutic effect on normal-pressure glaucoma of a test substance which comprises administering or adding the test substance to the above-described nonhuman mammal, an organ or a tissue thereof or cells collected from any of the same, and measuring a morphological defect, cell count, pressure, the expression amount or activity strength of a protein, the expression amount of a nucleic acid and/or the activity strength of an antibody in the organ, tissue and/or cells as indication(s) for the evaluation.
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