COMBINATION OF BENZYL-4,5-DIHYDRO-1H-IMIDAZOLE DERIVATIVE AND AN OPIOD RECPTOR LIGAND

摘要

The present invention refers to a combination of a Compound A, a benzyl-4,5-dihydro-1H-imidazole derivative according to formula (I) and a Compound B, an opioid receptor ligand; especially of xylometazoline or oxymetazoline and a µ-opioid receptor agonist, most preferably of xylometazoline or oxymetazoline and morphine; a medicament comprising this combination; a pharmaceutical formulation for nasal application comprising this combination; or the use of this combination for the treatment of the symptoms of pain, or the prevention or the prophylaxis of the symptoms of pain, whereas pain particularily encompasses visceral pain, chronic pain, cancer pain, acute pain or neuropathic pain, specifically involving also breakthrough pain.