A METHOD FOR ISOLATION AND PURIFICATION OF MONTELUKAST
摘要
A method of isolation of Montelukast of formula I from reaction mixtures, comprising conversion of the crude substance to well-crystallizing salts with primary amines in the environment of at least one organic solvent and acetonitrile, followed by re-crystallization of these salts with simultaneous removal of chemical impurities and use of the chemically pure salts of Montelukast with primary amines for direct transformation to the pharmaceutically useful amorphous form of Montelukast sodium of formula II.
申请公布号
WO2009006861(A2)
申请公布日期
2009.01.15
申请号
WO2008CZ00081
申请日期
2008.07.08
申请人
ZENTIVA, A.S.;HALAMA, ALES;JIRMAN, JOSEF;PETRICKOVA, HANA