<p>The present invention provides a method for treating tumors or tumor metastases in a patient, comprising administering to said patient simultaneously or sequentially a therapeutically effective amount of a combination of an anti-cancer agent or treatment that elevates pAkt levels in tumor cells and an IGF-IR kinase inhibitor of Formula (I) (e.g. OSI-906). Examples of such anti-cancer agents or treatments include doxorubicin, cisplatin, and ionizing radiation. The present invention also provides a pharmaceutical composition comprising an anti-cancer agent that elevates pAkt levels in tumor cells and an IGF-IR kinase inhibitor of Formula (I), in a pharmaceutically acceptable carrier. The present invention also provides a method of identifying tumor cells that will respond most favorably to treatment with a combination of an anti-cancer agent or treatment that elevates pAkt levels in tumor cells and an IGF-IR kinase inhibitor.</p>
申请公布号
WO2009009016(A1)
申请公布日期
2009.01.15
申请号
WO2008US08311
申请日期
2008.07.07
申请人
OSI PHARMACEUTICALS, INC.;EPSTEIN, DAVID, M.;BUCK, ELIZABETH, A.;EYZAGUIRRE, ALEXANDRA;MIGLARESE, MARK, R.
发明人
EPSTEIN, DAVID, M.;BUCK, ELIZABETH, A.;EYZAGUIRRE, ALEXANDRA;MIGLARESE, MARK, R.