SPIRO COMPOUNDS AS ANTAGONISTS OF TGF-BETA

摘要

The invention is related to compounds of formula (I) These compounds can be used as antagonists of the TGF-beta family tyle I receptors, Alk5 or Alk4. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e. g. renal fibrosis, pulmonary fibrosis and hepatic fibrosis), progressive cancers or other diseases for which reduction of TGF-beta family signalling activity is desirable.