| 摘要 |
The invention provides biomolecule binding ligands, collections of biomolecule binding ligands, and their use in the purification of biological mixtures and in the identification of ligands having an affinity for a substance. The ligand is a compound of formula (III) or a compound of formula (IV): wherein for compounds of formula (I) one of R1a, R1b, R2, R3 and R4 is a group comprising a linker attached to a support, and the others of R1a, R1b, R2, R3 and R4 are independently selected from optionally substituted C1-20 alkyl, optionally substituted C3-20 heterocyclyl or optionally substituted C5-20 aryl, and R1a, R1b and R2 are additionally selected from hydrogen, and R2 is additionally further selected from—S(═O)R5 and—C(═S)NR6R7, wherein R5, R6 and R7 are independently optionally substituted C1-20 alkyl, optionally substituted C3-20 heterocyclyl or optionally substituted C5-20 aryl, or, optionally, two or more of the others of R1a, R1b, R2, R3 and R4, together with the atoms to which they are bound, may form a ring; and for compounds of formula (II) one of R1a, R1b, R3 and R4 is a group comprising a linker attached to a support, and the others of R1a, R1b, R3 and R4 are independently selected optionally substituted C1-20 alkyl, optionally substituted C3-20 heterocyclyl or optionally substituted C5-20 aryl, and R1a, and R1b are additionally selected from hydrogen, or, optionally, two or more of the others of R1a, R1b, R3 and R4, together with the atoms to which they are bound, may form a ring. |
