发明名称 |
VERBESSERUNG DER AKTIVITÄT DER INSELZELLEN BEI DIABETES MELLITUS UND DESSEN PRÄVENTION |
摘要 |
The present invention discloses a method for therapeutically treating mammals, including but not limited to humans, to increase the relative insulin producing performance of endogenous pancreatic ²-cells and to cause differentiation of pancreatic epithelial cells into insulin producing ²-cells. Oral administration of a DP-IV inhibitor causes the active form of GLP-1 to be preserved longer under physiological conditions. The extended presence of GLP-1, in particular in the pancreatic tissue facilitates differentiation and regeneration of the ²-cells already present that arc in need of repair. These repaired insulin producing cells can contribute to the correction and maintenance of normal physiological glycemic levels. |
申请公布号 |
AT419036(T) |
申请公布日期 |
2009.01.15 |
申请号 |
AT20010927848T |
申请日期 |
2001.04.02 |
申请人 |
PROSIDION LIMITED |
发明人 |
DEMUTH, HANS-ULRICH;GLUND, KONRAD |
分类号 |
A61P3/10;C07D277/04;A61K31/00;A61K31/40;A61K31/401;A61K31/425;A61K31/426;A61K38/00;A61K45/00;A61K45/06;A61P5/50;A61P19/02;A61P29/00;A61P31/18;A61P37/06;A61P43/00 |
主分类号 |
A61P3/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|