AN IMPROVED PROCESS FOR THE MANUFACTURE OF CIS (-)-LAMIVUDINE

摘要

An improved process for the manufacture of Lamivudine. The process involves: (a) resolution of racemic lamivudine (intermediate of formula IX) to cis (±) lamivudine of formula (XII) by forming a crystalline salt and separating the product from an organic solvent by fractional crystallization; (b) resolution of cis (±) lamivudine to cis (-) isomer involving formation of S-binol adduct of formula (XIV).