| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a process for efficiently and readily producing an optically active 7-substituted-2-aminotetralin, with industrial advantage. <P>SOLUTION: The process for the preparation of an optically active 7-substituted-2-aminotetralin or its salt includes reduction of a 7-substituted-2-tetralone or a bisulfite adduct thereof, with a microorganism into an optically active 7-substituted-2-tetralol; introduction of a sulfonyl group into the hydroxyl group of the tetralol, to obtain an optically active 7-substituted-2-sulfonyloxytetralin; introduction of a nitrogen substituent into the resulting tetralin by the use of a nitrogen nucleophile through steric inversion, to obtain an optically active 2,7-substituted tetralin; and if necessary, the conversion of the nitrogen substituent into an unsubstituted amino group. <P>COPYRIGHT: (C)2009,JPO&INPIT</p> |
