发明名称 ANTIBODY FORMULATIONS
摘要 This invention relates to a shear and temperature stable antibody formulations that are more stable than compared to a standard formulation (such as 30 mM citrate, 10OmM NaCl, pH 6.5). The present invention's shear and temperature stable antibody formulations show reduced precipitation when subjected to stress conditions but the standard formulation had aggregated. This result was unpredictable because thermodynamically the two formulations are similar as seen by their DSC (differential scanning calorimeter) profiles.
申请公布号 WO2009009407(A1) 申请公布日期 2009.01.15
申请号 WO2008US69125 申请日期 2008.07.03
申请人 SMITHKLINE BEECHAM CORPORATION;BRISBANE, CHARLENE, E.;KETKAR, AMOL, SHARAD;LASHMAR, ULLA, TOVE 发明人 BRISBANE, CHARLENE, E.;KETKAR, AMOL, SHARAD;LASHMAR, ULLA, TOVE
分类号 A61K39/395 主分类号 A61K39/395
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