NEW HETEROCYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS

摘要

The present invention relates to compounds having the formula (I), its geometrical isomers, enantiomers, diastereomers and mixtures, or a pharmaceutically acceptable salt thereof, wherein Y is O, S or NR8; R1 is hydrogen or C1-6 alky!; R2 is hydrogen; R3 is -CONR5R6, -COR7, an imidazolyl, an imidazopyridinyl, an imidazopyridazinyl or a 1 H-indol-1-yl; R5, R6 are the same or different and are independently selected from hydrogen and C1-6 alkyl; R7 is a C1-6 alkyl; R8 is CN or C1-6 alkylsulfonyl; A is a monocyclic or bicyclic heterocyclic moiety selected from the group consisting of imidazolidin-1-yl, 1,3-oxazoIidin-3-yl, 2,5dihydro-1H-pyrrol-1-yl, 1,3-thiazol-3(2H)-yl, 1,3-thiazolidin-3-yl, pyrrolidin-1-yl, piperidin-1-yl, azepan-1-yl, 5,6-dihydro-4H-thieno[3,2-b]pyrrol-4-yl, hexahydro-4H,-thieno[3,2-b]pyrrol-4-yl, 2,3-dihydro-1H-thieno[3,4-b]pyrrol-1-yl, 1,3-benzothiazol-3(2H)-yl, 1,3-benzoxazol-3(2H)-yl, pyrazolo[1,5-al]pyridin-1 (2H)-yl, 3,4-dihydroisoquinolin-2(1H)-yl, 3,4-dihydroquinolin-1(2H)-yl, 1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl, 1,2,4,5-tetrahydra-3H-3-benzazepin-3-yl; for the manufacture of a medicament for the treatment or prevention of CNS disorders including epilepsy.