发明名称 |
VERFAHREN ZUR RATIONALEN MUTAGENESE VON A/BETA T- ZELL REZEPTOREN UND ENTSPRECHEND MUTIERTE MDM2- PROTEIN SPEZIFISCHE A/BETA T-ZELL REZEPTOREN |
摘要 |
<p>The invention relates to the rational mutagenesis of polypeptides ofα/βT-cell receptors that mediate an oncogen-specific T-cell response, nucleic acids encoding these and their use in the therapy, diagnosis and/or prevention of cancerous diseases. The invention further relates to a T-cell response-mediating MDM2-protein-specificα/βT-cell receptor, which has been rationally mutated by means of the method according to the present invention, and the uses thereof.</p> |
申请公布号 |
AT420110(T) |
申请公布日期 |
2009.01.15 |
申请号 |
AT20030769315T |
申请日期 |
2003.09.24 |
申请人 |
JOHANNES GUTENBERG-UNIVERSITAET MAINZ |
发明人 |
VOSS, RALF-HOLGER;MATTHIAS, THEOBALD |
分类号 |
C07K14/705;A61K38/17;C07K14/725;C12N15/12 |
主分类号 |
C07K14/705 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|