IMMUNOTHERAPY FOR HEMATOLOGICAL MALIGNANCIES

摘要

Methods and compositions for treating, preventing and/or managing various hematological malignancies are disclosed. Specific methods and compositions relate to use of tumor cells engineered to express antigen presenting molecules which present antigens recognized by invariant Natural Killer T (iNKT) cells and eliciting antitumor immune response from iNKT cells using such tumor cells, optionally in combination with an immunomodulatory compound.