发明名称 |
p38 MAP KINASE INHIBITORS |
摘要 |
Compounds of formula (I) are inhibitors of p38 MAP kinase, and are therefore of utility in the treatment of, inter alia, inflammatory conditions including rheumatoid arthritis and COPD: wherein: G is —N═ or —CH═; D is an optionally substituted divalent mono- or bi-cyclic aryl or heteroaryl radical having 5-13 ring members; R6 is hydrogen or optionally substituted C1-C3 alkyl; P represents hydrogen and U represents a radical of formula (IA); or U represents hydrogen and P represents a radical of formula -A-(CH2)z—X1-L1-Y—NH—CHR1R2 wherein A represents an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members; z, Y, L1, and X1 are as defined in the specification; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; and R2 is the side chain of a natural or non-natural alpha amino acid. |
申请公布号 |
EP2013175(A1) |
申请公布日期 |
2009.01.14 |
申请号 |
EP20070732629 |
申请日期 |
2007.05.01 |
申请人 |
CHROMA THERAPEUTICS LIMITED |
发明人 |
MOFFAT, DAVID, CHARLES, FESTUS;PINTAT, STEPHANE;DAVIES, STEPHEN |
分类号 |
C07D213/73;A61K31/44;A61P1/00;A61P29/00;A61P37/00 |
主分类号 |
C07D213/73 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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