PHARMACEUTICAL COMPOSITION FOR PREVENTINTION AND TREATMENT OF RESTENOSIS COMPRISING ISOXAZOLE DERIVATIVES

摘要

A pharmaceutical composition for preventing and treating the vascular restenosis is provided to improve the anti-restenosis activity and to promote the generation of endothelial cell. A pharmaceutical composition for preventing and treating the vascular restenosis comprises an isoxazole derivative represented by the formula 1 or its pharmaceutically acceptable salt, wherein R1 is a phenyl, furanyl or thienyl group substituted or unsubstituted with at least one substituted selected from an acyl group, an amino group, a craboalkoxy group, a carboxyl group, a carboxyamino group, -O-(C=O)-NH2, a cyano group, a halogen atom, a hydroxyl group, a nitro group, a thio group, an alkyl group, a cycloalkyl group, an aryl group, an alkoxy group, an aryloxy group, a sulfoxy group and a guanido group; m is 2 or 3; A is a bond, O, S, SO or S(=O)2; and R2 is an imidazolyl, pyrazolyl, triazolyl, tetrazolyl or pyridinyl group substituted or unsubstituted with at least one substituted selected from an acyl group, an amino group, a craboalkoxy group, a carboxyl group, a carboxyamino group, -O-(C=O)-NH2, a cyano group, a halogen atom, a hydroxyl group, a nitro group, a thio group, an alkyl group, a cycloalkyl group, an aryl group, an alkoxy group, an aryloxy group, a sulfoxy group and a guanido group.