发明名称 |
Cancer cell targeting gene delivery method |
摘要 |
The inventive chimeric ligand in the form of a fusion polypeptide of a single-chain antibody specific for Tag-72 surface antigen and GaLV envelope glycoprotein shows high transduction efficiency to cancer cells, specifically infects target cells and efficiently delivers a therapeutic gene. Accordingly, the inventive chimeric ligand can be effectively used for gene therapy to inhibit tumor growth and metastasis.
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申请公布号 |
US7473430(B2) |
申请公布日期 |
2009.01.06 |
申请号 |
US20040578839 |
申请日期 |
2004.03.15 |
申请人 |
INJE UNIVERSITY |
发明人 |
KIM YEON-SOO;SO IN SEOP;LEE YOUNG-KWAN;KIM JONGPIL;KANG MOONKYUNG;HONG HYOJEONG |
分类号 |
A61K35/12;C07K19/00;A61K38/00;C07K14/15;C07K16/30;C12N15/867;C12Q1/68 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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