DRUGS FOR AMELIORATING OCULAR CIRCULATORY DISORDERS

摘要

Drugs for ameliorating ocular circulatory disorders characterized by containing as the active ingredient 1,4-dihydropyridine derivatives represented by general formula (I) or acid-addition salts thereof, wherein each symbol is as defined in the specification. When dropped into the eyes, in particular, the above drugs enhance the blood flow in optic papillae and inhibit retinal vasoconstriction, a decrease in the blood flow in optic papillae and attenuation of VEP amplitude in the eyes with circulatory disorders caused by ET-1 without elevating the ocular tension. These facts suggest that the above drugs are useful as remedies for glaucoma, in particular with normal ocular tension, caused by ocular circulatory disorders, retinal pigment degeneration, macular degeneration, ischemic optic neuritis, iridocyclitis, retinal arterial obliteration, retinal phlebemphraxis, diabetic retinitis, choroid diseases following retinal lesions, retinal/choroid diseases associated to systemic diseases, etc. <CHEM>