| 摘要 |
Compounds of the formula II: wherein R2 is the side chain of leucine, isoleucine, cyclohexylglycine, O-methyl threonine, 4- fluoroleucine or 3-methoxyvaline; R3 is H, methyl or F; Rq is thfluoromethyl and Rq' is H or Rq and Rq' define keto; Q is a p-(C1-C6alkylsulphonyl)phenyl- or an optionally substitued 4-(C1- C6alkyl)piperazin-1 -yl-thiazol-4-yl- moiety have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin K, such as osteoporosis, osteoarthritis, rheumatoid arthritis or bone metastases.
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