POLYFUNCTIONAL FULLERENE C60 AMINO ACID DERIVATIVES

摘要

The invention relates to novel polyfunctional fullerene C60 aminoacid der ivatives of formula (1), wherein R=H, mono- or dihydroxyalkyl, aminoalkyl, h aloidalkyl, mono- or dinitroxyalkyl or maleinimide mm; N-Z are the .alpha.,. beta.,.gamma., .omega.-aminoacid of general formula NH-CmH2 m-COOM or (II) - N- COOM, wherein m=2-5 and M is a nitroxyalkyl group, an alkyl group or an a lkali metal salt, or a biologically active dipeptide, to methods for the pro duction thereof and to a method for binding fullerene derivatives with SH-co ntaining proteins. The invention also relates to the use of nitroxyalkyl-(fu llerenyl)aminoacids as nitrogen monoxide donors and to the use of said nitro xyalkyl-(fullerenyl)aminoacids in the form of quick-acting vasodilatators fo r antihypertensive therapy. A method for inhibiting a metastasis process and a method for enhancing antileukemik activity of cyclophosphamide are also d isclosed.