| 摘要 |
The invention relates to novel methods and means for providing proteinaceous substances, such as peptides, polypeptides, glycoproteins, lipoproteins and complex compounds comprising the former in combination with other substances, such as nucleic acids, membrane structures, carbohydrate structures, with cross-beta structures, which enhance the immunogenicity of said proteinaceous substance. The resulting peptides, proteins, glycoproteins, etc. are preferably used in vaccines. The invention provides a method for producing an immunogenic composition comprising at least one peptide, polypeptide, protein, glycoprotein and/or lipoprotein, comprising providing said composition with at least one cross-beta structure. The invention also discloses the use of cross-beta structures in the preparation of a vaccine for the prophylaxis of an infectious disease. The invention further provides a method for improving immunogenicity of a composition comprising at least one peptide, polypeptide, protein, glycoprotein and/or lipoprotein, comprising contacting at least one of said peptide, polypeptide, protein, glycoprotein and/or lipoprotein with a cross-beta inducing agent, thereby providing said composition with additional cross-beta structures. |
