BETA2-MICROGLOBULIN AND C REACTIVE PROTEIN (CRP) AS BIOMARKERS FOR PERIPHERAL ARTERY DISEASE

摘要

The present invention relates to the use of Beta-2-microglobulin (B2M) and C-reactiva protein (CRP) levels as biomarkers of peripheral artery disease (PAD) and/or coronary artery disease. In one aspect the invention features a method for classifying peripheral artery disease status in a subject comprising: detecting a level of B2M in a blood sample from a subject, wherein the subject has one or more cardiovascular disease symptoms or risk factors; and detecting a level of CRP in a blood sample from the subject, wherein levels of B2M and CRP detected are indicative of a PAD status in the subject. In another aspect, the invention provides for a kit incorporating the use of B2M and CRP as biomarkers for the detection of a PAD status of a subject.