New pyrido[3',2':4,5]furo[3,2-d]pyrimidine deratives

摘要

The present disclosure relates to a pyridofuropyrimidine derivative of formula (I): wherein G¹ is a group chosen from -CR⁶R⁷- and -O- wherein R⁶ and R⁷ are independently chosen from hydrogen atoms and C_1-4 alkyl groups; R¹ and R² are independently chosen from hydrogen atoms and C_1-4 alkyl groups; R³ is chosen from C_1-4 alkyl, C_1-4 alkoxy, amino, hydroxy, mono-C_1-4alkylamino, di-C_1-4alkylamino, C_3-8cycloalkylamino, aryl, heteroaryl and saturated N-containing heterocyclyl groups which are bound to the pyridine ring through their nitrogen atom, all of them being optionally substituted by one or more substituents chosen from halogen atoms and hydroxy, C_1-4 alkyl, C_1-4alkoxy-C_1-4alkyl, aryl-C_1-4alkyl, -O(CO)OR⁸, C_1-4 alkoxy, -(CO)NR⁸R⁹, -CN, -CF₃, -NR⁸R⁹, -SR⁸ and -SO₂NH₂ groups wherein R⁸ and R⁹ are each independently chosen from a hydrogen atom or a C_1-4 alkyl group; R⁴ and R⁵ are independently chosen from hydrogen atoms, C_1-4alkyl groups, hydroxyl-C_1-4alkyl groups and groups of formula (II): wherein p and q are integers chosen from 0, 1, 2 and 3; A is either a direct bond or a group chosen from -CONR¹⁴-, -NR¹⁴CO-, -O-, -COO-, -OCO-, -S-, -SO- and -SO₂-, wherein each R¹⁰, R¹¹, R¹², R¹³ and R¹⁴ are independently chosen from a hydrogen atom and a C_1-4alkyl group and G² is chosen from aryl, heteroaryl and heterocyclyl groups; wherein the group G² is optionally substituted by one or more substituents chosen from halogen atoms and C_1-4alkyl, hydroxy, oxo, C_1-4alkoxy-C_1-4alkyl, aryl-C_1-4alkyl, -(CO)OR¹⁶, C_1-4alkoxy, -(CO)NR¹⁶R¹⁷, -CN, -CF₃, -NR¹⁶R¹⁷-SR¹⁶ and -SO₂NH₂ groups; wherein R¹⁶ and R¹⁷ each independently chosen from hydrogen atom and a C_1-4alkyl group and the pharmaceutically acceptable salts and N-oxides thereof.