发明名称 |
N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals |
摘要 |
The present invention comprises N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, their physiologically acceptable salts and functional derivatives that exhibit peroxisome proliferator activated receptor (PPAR) PPARdelta and PPARgamma agonist activity. The structure of the compounds of the invention are defined by Formula I below, And the isomers thereof wherein the various substituents are defined herein, including their physiologically acceptable salts. Processes for the compounds preparation are also disclosed. The compounds are suitable for the treatment of fatty acid metabolism and glucose utilization disorders, disorders relating to insulin resistance are involved as well as demyelinating and other neurodegenerative disorders of the central and peripheral nervous system. |
申请公布号 |
ZA200801987(B) |
申请公布日期 |
2008.12.31 |
申请号 |
ZA20080001987 |
申请日期 |
2008.03.03 |
申请人 |
SANOFI-AVENTIS |
发明人 |
KEIL, STEFANIE;MATTER, HANS;SCHOENAFINGER, KARL;URMANN, MATTHIAS;GLIEN, MAIKE;WENDLER, WOLFGANG;SCHAEFER, HANS-LUDWIG;FALK, EUGEN |
分类号 |
A61K;A61P;C07D |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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