发明名称 |
POST-SCREENING LABELING OF ON-BEAD COMPOUNDS |
摘要 |
<p>The present invention relates to new on bead chemistry to produce compound libraries used in improved screening methods, allowing the direct solution confirmation of on-bead screening hits without compound decoding and resynthesis. More specifically, the invention relates to on-bead compounds having the formula B - L - C - S, wherein - represents a bond or any stable covalent spacer, B is a solid support to which a plurality of L-C-S molecules are covalently attached, L is a cleavable linker for covalently linking C to the solid support, C is a covalent linking core comprising at least one protected labeling functional group for covalently linking of a label or a detection molecule, S is a spacer comprising at least one protected or unprotected functional group for on-bead compound derivatization, and wherein L and C are selected so that (i) the linker L and the protected labeling functional group are not affected by side chain deprotection during on-bead compound derivatization, (ii) the linker L and any synthetic molecule attached to S are not affected by deprotection of labeling functional group and labeling reaction step, (iii) covalent linkage of the label or the detection molecule or any synthetic molecule attached to S are not affected by cleavage of the linker L.</p> |
申请公布号 |
WO2009000775(A1) |
申请公布日期 |
2008.12.31 |
申请号 |
WO2008EP57878 |
申请日期 |
2008.06.20 |
申请人 |
NOVARTIS AG;AUER, MANFRED;HINTERSTEINER, MARTIN;KIMMERLIN, THIERRY |
发明人 |
AUER, MANFRED;HINTERSTEINER, MARTIN;KIMMERLIN, THIERRY |
分类号 |
C40B20/00;C07C271/18;C07D249/04;C07D311/88;C40B40/10 |
主分类号 |
C40B20/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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