发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF PRO-APOPTOTIC GENES |
摘要 |
The invention relates to one or more inhibitors, in particular siRNA compounds, which down-regulate the expression of a pro-apoptotic gene selected from the group consisting of TP53; HTRA2; KEAP1; SHC1-SHC, ZNHIT1, LGALS3 and HI95. The invention also relates to a pharmaceutical composition comprising the compound, and a pharmaceutically acceptable carrier. The present invention further provides methods of treating a subject afflicted with a disease or a condition associated with those genes, comprising administering to the subject a pharmaceutical composition in a therapeutically effective dose so as to thereby treat the subject. |
申请公布号 |
WO2009001359(A2) |
申请公布日期 |
2008.12.31 |
申请号 |
WO2008IL00874 |
申请日期 |
2008.06.26 |
申请人 |
QUARK PHARMACEUTICALS, INC.;KALINSKI, HAGAR;METT, IGOR;FEINSTEIN, ELENA |
发明人 |
KALINSKI, HAGAR;METT, IGOR;FEINSTEIN, ELENA |
分类号 |
A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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