发明名称 |
N-OXIDES OF VENLAFAXINE AND O-DESMETHYLVENLAFAXINE AS PRODRUGS |
摘要 |
<p>The invention concerns venlafaxine-N-oxide and O-desmethylvenlafaxine-N-oxide as prodrugs of venlafaxine and its major (active) metabolite O-desmethylvenlafaxine respectively, to pharmaceutical compositions containing these N-oxides, to methods for preparing them, and methods for preparing compositions. The invention relates to N-oxide, having formula (1), wherein R1 is H or CH3, and tautomers, stereoisomers, hydrates and solvates thereof. The invention also relates to the uses of the N-oxides and compositions, particularly for the manufacture of medicaments useful in the treatment of affections or diseases effectively treatable - albeit with side effects - with venlafaxine.</p> |
申请公布号 |
WO2009000797(A1) |
申请公布日期 |
2008.12.31 |
申请号 |
WO2008EP57939 |
申请日期 |
2008.06.23 |
申请人 |
SOLVAY PHARMACEUTICALS B.V.;TURSKI, LECHOSLAW A.;STOIT, AXEL;KRUSE, CORNELIS G.;VADER, SANDER;TULP, MARTINUS TH.M. |
发明人 |
TURSKI, LECHOSLAW A.;STOIT, AXEL;KRUSE, CORNELIS G.;VADER, SANDER;TULP, MARTINUS TH.M. |
分类号 |
C07C291/04;A61K31/135;A61P25/24 |
主分类号 |
C07C291/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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