发明名称 |
PROCESS FOR ISOLATING MONO-CARBOXY SUBSTITUTED PROBUCOL DERIVATES |
摘要 |
<p>A process for isolating a compound of formula (I) or a salt thereof, where X and R1 are as defined in the specification, from a mixture containing it, and the corresponding diacid and dihydroxy derivative, said process comprising (i) adding to an organic solution containing said compounds, water and a one or more salts, all of which are bases selected from a carbonate or hydrogen carbonate base, (ii) separating the aqueous phase containing the compound of formula (II) from the organic phase containing the compounds of formula (I) and (III); then (iii) recovering the compound of formula (I) from remaining organic phase. The process provides for efficient isolation of the target compound, even on a large scale.</p> |
申请公布号 |
WO2009002263(A1) |
申请公布日期 |
2008.12.31 |
申请号 |
WO2008SE50765 |
申请日期 |
2008.06.25 |
申请人 |
ASTRAZENECA AB;PARKER, JEREMY, STEPHEN;SNAPE, EVAN, WILLIAM |
发明人 |
PARKER, JEREMY, STEPHEN;SNAPE, EVAN, WILLIAM |
分类号 |
C07C319/28 |
主分类号 |
C07C319/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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