发明名称 |
New crystalline form III of agomelatine, method of preparing same and pharmaceutical compositions containing same |
摘要 |
<p>Crystalline form III of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide is new. The compound is confirmed by powder X-ray diffraction pattern as given in the specification. An independent claim is included for preparation of the crystalline form III of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide involves: heating agomelatine at 110[deg]C until fully melted, and then slowly cooled until recrystallization occurs. ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Gastrointestinal-Gen; CNS-Gen; Cardiovascular-Gen.; Neuroleptic; Muscular-Gen.; Immunomodulator; Eating-Disorder-Gen.; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Neuroprotective; Dermatological; Antimigraine; Cerebroprotective; Endocrine-Gen.; Cytostatic; Analgesic; Contraceptive. MECHANISM OF ACTION : Melatoninergic system receptor agonist; 5-HT(hydroxytryptamine)-2C receptor antagonist. No biological data given.</p> |
申请公布号 |
EP2008993(A1) |
申请公布日期 |
2008.12.31 |
申请号 |
EP20080017458 |
申请日期 |
2006.08.02 |
申请人 |
LES LABORATOIRES SERVIER |
发明人 |
COQUEREL, GERARD;LINOL, JULIE;SOUVIE, JEAN-CLAUDE |
分类号 |
C07C233/18;A61K31/165;A61P3/00;A61P9/00;A61P15/08;A61P25/00;A61P37/00;C07C231/24 |
主分类号 |
C07C233/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|