发明名称 |
METHOD FOR TREATING WARM-BLOODED VERTEBRATES WITH HALIDE-FREE GLUCOSAMINE-ACIDIC DRUG COMPLEXES |
摘要 |
<p>The invention provides a method of treating a warm-blooded vertebrate. The vertabrate may be a human being or a lower animal. The treatment method involves administering to the vertebrate in need of such treatment a pharmaceutically effective amount of a complex of halide-free glucosamine and a therapeutic drug having a pKa of less than 7. Preferably, the complex is stabilized by coating it with at least one pharmaceutically acceptable polymer comprising a water-soluble, water-immiscible and/or water-swellable homopolymer and/or copolymer. Suitable polymers include carboxypolymethylene homopolymers and copolymers; polyethylene glycol homopolymers and copolymers; povidone homopolymers and copolymers; polyacrylic acid homopolymers and copolymers; polyacrylamide homopolymers and copolymers; polysaccharides; and mixtures of two or more of the foregoing polymers. The resultant polymer-coated complex will be stable upon exposure to ambient temperature and/or the atmosphere.</p> |
申请公布号 |
WO2009002299(A1) |
申请公布日期 |
2008.12.31 |
申请号 |
WO2007US14626 |
申请日期 |
2007.06.22 |
申请人 |
GLUCONOVA LLC |
发明人 |
COWAN, ALAN;RAFFA, ROBERT, B.;TALLARIDA, RONALD, J. |
分类号 |
C07H5/06 |
主分类号 |
C07H5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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