发明名称 |
Compositions and methods related to modified retroviral vectors for restricted, site specific integration |
摘要 |
Embodiments of the invention include compositions comprising and methods utilizing a retroviral integrase complex comprising a recombinant integrase having a domain comprising a non-native protein binding site, and a DNA binding protein comprising a DNA binding domain and a peptide binding domain that binds the non-native protein binding site of the recombinant integrase.
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申请公布号 |
US7470777(B2) |
申请公布日期 |
2008.12.30 |
申请号 |
US20050317330 |
申请日期 |
2005.12.22 |
申请人 |
IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.;UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
MCCRAY, JR. PAUL B.;SINN PATRICK L.;VOYTAS DANIEL F.;DAI JUNBIAO |
分类号 |
A61K39/385;A61K39/00;A61K39/12;A61K39/21;C07K14/00 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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