发明名称 |
SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: TISSUE SELEX |
摘要 |
This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, glioblastomas, and lymphomas are described.
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申请公布号 |
CA2219807(C) |
申请公布日期 |
2008.12.30 |
申请号 |
CA19962219807 |
申请日期 |
1996.05.01 |
申请人 |
NEXSTAR PHARMACEUTICALS, INC. |
发明人 |
CHEN, HANG;JENSEN, KIRK B.;GOLD, LARRY;MORRIS, KEVIN N.;STEPHENS, ANDREW |
分类号 |
C12Q1/68;C07H21/00;C12N15/10;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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