发明名称 |
Chemo-enzymatic process for the preparation of escitalopram |
摘要 |
A process for preparing an intermediate for synthesizing escitalopram and the pharmaceutically acceptable salts thereof from 4-(4-dimethylamino)-1-(4'-fluorophenyl)-1-(hydroxybutyl)-3-(acyloxymethyl)benzonitrile is described. The process involves converting said intermediate into the (S+) enantiomer of citalopram by means of enzymatic enantiomeric resolution.
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申请公布号 |
US7470526(B2) |
申请公布日期 |
2008.12.30 |
申请号 |
US20060544205 |
申请日期 |
2006.10.06 |
申请人 |
ADORKEN TECHNOLOGY SPA |
发明人 |
COTTICELLI GIOVANNI;ROCCHIETTI SILVIA;TERRENI MARCO;PREGNOLATO MASSIMO;SALVETTI RAUL |
分类号 |
C12P17/04;C12P41/00 |
主分类号 |
C12P17/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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