<p>Fish are immunized by a mass vaccination method, such as by immersion in water containing an attenuated strain of a pathogenic bacterium that does not effectively cause disease in fish when the non-attenuated pathogenic bacterium is exposed to the fish by immersion. An illustrative example of the method is for immunizing against coldwater disease caused by Flavobacterium psychrophilum, which may be attenuated by serial passage in media containing increasing amounts of an antibiotic, such as rifampicin.</p>
申请公布号
WO2009002395(A1)
申请公布日期
2008.12.31
申请号
WO2008US06998
申请日期
2008.06.03
申请人
UNIVERSITY OF IDAHO;CAIN, KENNETH, D.;LAFRENTZ, BENJAMIN, R.;LAPATRA, SCOTT
发明人
CAIN, KENNETH, D.;LAFRENTZ, BENJAMIN, R.;LAPATRA, SCOTT